What is Tadalafil?

Man thinkingTadalafil is a medication used to treat erectile dysfunction, the inability to get or keep an erection. Erectile dysfunction, sometimes called impotence, has several causes. Causes of erectile dysfunction include heart disease, high blood pressure, diabetes, low testosterone, stress, depression, and most commonly being due to a narrowing of the arteries that take blood to the penis. Tadalafil is a phosphodiesterase (PDE) inhibitor which helps to relax and widen blood vessels and improves the flow of blood. In erectile dysfunction, it increasing blood flow to the penis during sexual stimulation can help to cause and maintain an erection.

Benefits of Tadalafil

Tadalafil is also used for symptoms of benign prostatic hyperplasia (BPH), an enlarged prostate, which include difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency in adult men. Tadalafil has the ability to make these symptoms less severe and reduce the chance that prostate surgery will be needed. The FDA has approved Tadalafil for treatment of BPH.

 Tadalafil is also used in men and women to treat the symptoms of pulmonary arterial hypertension (PAH). This is a high blood pressure that occurs in the main artery that carries blood from the right side of the heart (the ventricle) to the lungs. Tadalafil is used to improve the ability to exercise in people with PAH, which can cause shortness of breath, dizziness, and tiredness.

Side Effects of Tadalafil

Use Tadalafil exactly as directed by your doctor. Do not use more than prescribed. If too much is used, the chance of side effects or other problems is increased. Do not use Tadalafil if you are also using a nitrate drug for chest pain or heart problems. This includes Nitroglycerin, Isosorbideinitrate, and Isosorbide Mononitrate. Taking Tadalafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.


  • Phosphodiesterase Inhibitor – Phosphodiesterase-5 inhibitors (PDE-5 inhibitors) are taken before you plan to be sexually active. PDE-5 inhibitors will result in an erection only if you are sexually stimulated.
  • Vasodilator – Vasodilators are medications that open (dilate) blood vessels. They work directly on the muscles in the walls of your arteries, preventing the muscles from tightening and the walls from narrowing. As a result, blood flows more easily through your arteries, your heart doesn’t have to pump as hard and your blood pressure is reduced.


  • Tablet


  • If not on the daily dose regimen, Tadalafil is taken approximately 1 hour before expected intercourse, but preferably not after a heavy or high-fat meal

Therapeutic Effects

Effective for treatment of:

  • Erectile dysfunction – an inability to develop or maintain an erection
  • Benign prostatic hyperplasia – enlarged prostate
  • Pulmonary hypertension – a type of high blood pressure that affects the arteries in the lungs and the right side of your heart


Tadalafil is recommended for use in individuals with erectile dysfunction, benign prostatic hyperplasia and pulmonary hypertension


  • Hypersensitivity to Tadalafil
  • Unstable angina or angina during intercourse – chest pain or discomfort
  • Uncontrolled cardiac arrhythmias – heart rhythm problems
  • Nitrate/Nitrite therapy
  • Hypotension
  • Uncontrolled hypertension
  • Retinitis pigmentosa – a genetic condition that causes retinal degeneration and eventual vision loss
  • Hepatic cirrhosis – chronic degenerative disease in which normal liver cells are damaged and are then replaced by scar tissue

Cautious Use

  • Renal insufficiency
  • Anatomic deformity of the penis
  • Sickle cell anemia
  • Leukemia – cancer of the bone marrow
  • Active bleeding or a peptic ulcer
  • Coronary artery disease
  • Multiple myeloma – cancer of plasma cells
  • GERD – acid reflux disease
  • Retinitis pigmentosa

Side Effects

Body – These effects can appear anywhere in the body

  • Asthenia
  • Facial edema
  • Fatigue
  • Pain

Central Nervous System – These effects impact the brain, spinal cord, and nerve messages throughout the body

  • Dizziness
  • Hypesthesia
  • Insomnia
  • Paresthesia
  • Somnolence
  • Vertigo

Cardiovascular – These effects pertain to the heart and circulation

  • Angina pectoris
  • Chest pain
  • Hypotension
  • Myocardial infarction
  • Postural hypotension
  • Palpitations
  • Syncope
  • Tachycardia

Gastrointestinal – These effects are found in the digestive tract which begins at the mouth, goes through the stomach, and ends with the intestines and rectum

  • Abnormal liver function tests
  • Dry mouth
  • Dysphagia
  • Esophagitis
  • Gastritis
  • Increased GGTP
  • Loose stools
  • Nausea
  • Upper abdominal pain
  • Vomiting
  • Gastroesophageal reflux disease
  • Hemorrhoidal hemorrhage
  • Rectal hemorrhage


Skin – These effects impact the skin

  • Pruritis
  • Rash
  • Sweating


Urogenital – These effects impact the reproductive system and urine

  • Erections increased
  • Spontaneous penile erection


Eyes – These effects impact the eyes

  • Blurred vision
  • Changes in color vision
  • Conjunctivitis
  • Eye pain
  • Lacrimation increase
  • Swelling of eyelids


Respiratory – These effects impact the nose, nasal passages, pharynx, larynx, trachea, bronchi, and lungs

  • Dyspnea
  • Epistaxis
  • Pharyngitis

Otologic – These effects impact hearing

  • Sudden decrease or loss of hearing
  • Tinnitus